The meta-analysis looked at 21 randomised trials that compared beta-blockers in patients diagnosed with heart failure with reduced ejection fraction, and looked at their influence on mortality. A total of 23,122 patients were included in the analysis across the 21 trials analysed.
Of all the beta-blockers analysed, atenolol and carvedilol had the greatest effect on reducing mortality, when compared with placebo or standard treatment, reducing the risk of death by 47% and 44% respectively. Bisoprolol was the next best, reducing risk by 35% compared to placebo or standard treatment. However, when these three were compared to other beta-blockers for the same outcome, there were no significant differences between them.
What it means for GPs?
The authors concluded that, given the lack of differences in improvement of mortality with individual beta-blockers, they considered it ‘pragmatic’ to infer that three agents – bisoprolol, sustained release metoprolol succinate, and carvedilol – should be used They said these drugs had been tested more extensively and had been shown to be superior to placebo.
Dr Ahmet Fuat, cardiology GPSI in Darlington: ‘The study concurs with current GP practice. The three beta blockers they recommend are the most commonly used, though I would also suggest nebivolol for older patients with erectile dysfunction.’