This site is intended for health professionals only

Antibody study suggests 12% of GPs may have had Covid-19

Patient-facing health and care workers are most likely to have Covid-19 antibodies, researchers have found.

Researchers asked 100,000 randomly selected volunteers to use at-home finger-prick tests to find antibodies, and using those results, estimated 3.4 million people in England have had the virus.

In all, around 6% of people had antibodies, the study led by Imperial College London found.

But in patient-facing healthcare workers – such as GPs – 12% had antibodies, while this number rose to 16% for care home workers. In non-key workers, the rate was 5%.

The estimations far exceed the total number of confirmed cases in England, which stands at 275,200.

The researchers found London to be the worst-hit area, with more than twice the national average for infections (13%), while the South West had the lowest (3%).

The study also found that Black, Asian and minority ethnic (BAME) individuals were between two and three times as likely to have had the virus compared to white people, mirroring previous research findings, though the gap did reduce after researchers took factors such as age and key workers status into account.

People from the poorest areas were also more likely to have had Covid-19 (7%) compared to those from the least deprived (5%), the report added, which is in line with previous ONS statistics on deprivation.

People living in households of more than seven people were more than twice as likely to have been infected than those living alone or with one other person (13% and 5% respectively), the study found.

The research found young people aged between 18-24 had the highest rates of infection (8%) and were more than twice as likely to test positive than adults aged 65 to 74, who were least likely to have had the virus (3%).

Overall, the highest number of positive test results came from those who reported confirmed or suspected Covid-19 earlier in the pandemic, in March and April.

Meanwhile, the Covid-19 fatality ratio – the proportion of infected people who died – was calculated by researchers to be 0.9%, similar to other countries such as Spain.

Almost all participants (96%) who had a previous infection confirmed by a swab test also had antibodies, and those who had suffered severe Covid-19 symptoms were twice as likely to have antibodies than those with no symptoms.

Professor Graham Cooke, study lead and National Institute for Health Research (NIHR) professor of infectious diseases, said: ‘There are still many unknowns with this new virus, including the extent to which the presence of antibodies offers protection against future infections.

‘Using the finger-prick tests for large scale home testing has given us clearest insight yet into the spread of the virus in the country and who has been at greatest risk. These data will have important implications for decisions around ongoing control measures in England.’

Kelly Beaver, Ipsos MORI managing director of public affairs, said: ‘The thorough and rigorous work carried out by Imperial College London has allowed us to find a robust at home finger prick test for Covid-19 antibodies.

‘This is the springboard for developing a far greater understanding of Covid-19 antibodies and how prevalent they are in the population through our large-scale antibody study, conducted with over 100,000 members of the public.’

The study is set to be repeated this autumn, with 200,000 participants. 

The results mirror the early results from the UK Biobank study into antibodies, which had found 7% of the UK population had been infected with Covid-19 by May/June. However, a recent BMA survey found that one fifth of GPs believe they have had Covid-19.