This site is intended for health professionals only

At the heart of general practice since 1960

Diuretics 'best in patients at risk of heart failure'

By Nigel Praities

GPs should use diuretics first-line in hypertensive patients at risk of developing heart failure, say Italian researchers.

In a comparative analysis of data from 220,000 patients, the researchers looked at which blood pressure treatment is the best at preventing the development of heart failure.

The meta-analysis found diuretics treatment was associated with a 41% reduced risk of developing heart failure, compared with placebo. This compared with a 29% reduced risk with ACE inhibitors, 24% with angiotensin receptor blockers, 23% reduced risk with calcium channel blockers and a 13% reduced risk with beta blockers, compared with placebo.

Lead author Dr Sebastiano Sciarretta, a cardiologist at the University of Rome, said: ‘Our findings support the use of these agents as first-line antihypertensive strategy to prevent heart failure in patients with hypertension at risk to develop heart failure.'

Arch Intern Med 2010; published early online Nov 8

Diuretics 'best in patients at risk of heart failure'

Rate this article 

Click to rate

  • 1 star out of 5
  • 2 stars out of 5
  • 3 stars out of 5
  • 4 stars out of 5
  • 5 stars out of 5

0 out of 5 stars

Have your say