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Covid-19 Primary Care Resources


Covid vaccine and pre-existing allergies



Guidance on the Pfizer/BioNTech, AstraZeneca and Moderna Covid-19 vaccinations for people with pre-existing allergies

This information is sourced from The PHE Greenbook, The NHS Specialist Pharmacy Service and the MHRA:

Key Points

  • There are very few individuals who cannot receive the Pfizer BioNtech, AstraZeneca or Moderna vaccines
  • The vaccine should NOT be administered to those with a previous immediate-onset anaphylaxis to a previous dose of the same vaccine or any excipient of the same vaccine
  • The Pfizer BioNTech and Moderna vaccines should NOT be administered to those with a known PEG allergy as this is one of the excipients of the vaccine
  • Those with a known allergies to multiple classes of medication or a history of unexplained anaphylaxis should only receive the Pfizer BioNTech or Moderna vaccine on the advice of an allergy specialist as it may indicate underlying PEG allergy
  • Those with food, insect bite or latex allergies, or allergies to a single known medication, can receive the vaccine

Public Health England has stated that GPs can consider ‘pre-treatment’ with antihistamines and a 30-minute observation after vaccination with any Covid jab for patients with a history of an immediate allergic reaction of any severity to another (non-mRNA COVID-19) vaccine or injectable therapy or patients with a history of anaphylaxis due to any cause. This is in support of CDC guidelines

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Written by Dr Rajiv Sharma