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Should we use statins for primary prevention of cardiovascular disease?

04 Oct 2010

Why start to prevent a cardiovascular event only when a patient has had one, asks Dr George Kassianos. However, Dr Matt Hughes argues we need better data.

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READERS' COMMENTS

Anonymous,
05 Oct 2010
Dr Kassianos quotes a Relative Risk Reduction of 44% But in the healthy group tested, events are very rare. He should quote the Number Needed to Treat to prevent 1 event with Rosuvastatin & that's a vast number ANDREW GRAY
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Anonymous,
05 Oct 2010
Here is a lot of intressting reading:

http://www.ravnskov.nu/cholesterol.htm henrik bugge
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Anonymous,
06 Oct 2010
Andrew Gray is right. I should have given the NNT.
I did, but the Editor cut it out. Here is the sentence I had in my manuscript: "The calculated number needed to treat (NNT) with rosuvastatin to prevent the occurrence of a first major cardiovascular event was 31 primary prevention patients for 4 years".
With simvastatin one month costing less than one cup of coffee, can we really still go on discussing whether primary prevention works, or can we really wait for the patient's risk to rise to a stuggering 20% before we do something? George Kassianos
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Anonymous,
08 Oct 2010
This comment advertises his books rather than adding to the debate:
henrik bugge - t�by | 05 Oct 10
Here is a lot of intressting reading: http://www.ravnskov.nu/cholesterol.htm
George Kassianos
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